MEC8049: Orthopaedic engineering
Part 2: Dr Piergiorgio Gentile (STB, mezzanine floor, M2a)
Dr Ana Ferreira Duarte (STB, second floor 2.21)
From Newcastle. For the world.
Part 2 Date Room Lecturer Topic 9th March at 1 pm MERZ L302 AFD Introduction 10th March at 3 pm MERZ L302 AFD 1. Biological strategies for improving osseointegration
16th March at 1 pm MERZ L302 PG 2. Biological surface functionalisation to improve biological
features 17th March at 3 pm MERZ L302 PG 2. Biological surface coating technologies: Layer-by-Layer
23rd March at 1 pm MERZ L302 AFD 3. Additive manufacturing: bioprinting
24th March at 3 pm MERZ L302 AFD & PG 3. Additive manufacturing: 3D printing
27th April at 1 pm MERZ L302 AFD 4. Cell therapy 28th April at 3pm MERZ L302 PG 4. Bone models for orthopaedics
04th May at 1 pm MERZ L302 AFD 5. Biological Complications and Their Management 05th May at 3 pm MERZ L302 PG 6. An overview on the orthopaedic standards
11th -12th May Revision
week
AFD & PG Consultancy hours for the Report 2
From Newcastle. For the world.
1. Biological strategies for improving osseointegration (AFD)
Roach (2007) J Mater Sci Mater Med 18:1263 Gittens et al. (2011) Biomaterials 32:3395
Part 2
From Newcastle. For the world.
2. Biological surface functionalisation to improve biological features (PG)
Richardson et al. (2015) Science 348, aaa2491
Part 2
From Newcastle. For the world.
3. Additive manufacturing: bioprinting & 3D printing (AFD & PG)
Part 2
From Newcastle. For the world.
4. Cell therapy & bone models for orthopaedics (AFD & PG)
Part 2
Measurable data to predict the risks
Enables3Rs
Tissue and organ regeneration
Understanding/analysis and treatment of diseases (e.g. cancer, osteoarthritis, osteoporosis, etc.)
Drug discovery and evaluation
https://www.frontiersin.org/articles/10.3389/fbioe.2017.00040/full
From Newcastle. For the world.
5. Biological complications and their management (AFD)
Part 2
Figure 1. (ac) X-ray of a 36 year-old male patient few days following curettage of a low-grade chondrosarcoma of the left proximal tibia. (b and c) Follow-up radiographs 7 and 13 months following index surgery showing integration but no resorption of the artificial bone graft substitute. https://www.nature.com/articles/s41598-017-02048-w
https://www.nature.com/articles/s41598-017-02048-w/figures/1
From Newcastle. For the world.
6. An overview on the orthopaedic standards (PG)
Part 2
From Newcastle. For the world.
Assessment (%)
Written examination Report 1 (Part 1) Report 2 (Part 2)
90 min 4 long questions, 2 from each half of the course (Part 1 & 2)
Report 1 is due in week 30
Report 2 is due in week 37 (11 May*)
*These dates are to be confirmed
Assessment
From Newcastle. For the world.
Projects
Solve a device issues for a particular musculoskeletal
application (eg. THR, cancer drug screening, fixation
plates and screws, etc)
1. Antibacterial coatings on metals
2. Antibacterial coatings on polymers
3. Osseointegration of polymeric implants
4. Osseointegration of porous metallic implants
5. Bioprinting vs 3D printing on metals or polymers
6. Bioprinting of in vitro bone models
7. Issues and troubleshooting on bioprinting for
orthopaedics
8. More are coming!
From Newcastle. For the world.
Report Structure
Structure (limit 20 pages)
? Abstract (200 words)
? Introduction
? Motivation & background
? Literature Review
? Methods*
? Discussion and Analysis
? Conclusion
Marking criteria
? Capability (70%)
? Quality of background (30%)
? Description and justification of selected process and/or manufacturing route to solve specific implant issue (20%)
? Commercial viability, lifecycle, regulations and standards (20%)
? Organisation
? Relevance and prioritisation
? Deployment of evidence
? Making logically reasoned argument
Basic requirements Presentation (30%)
? Task specification
? Style and format
? Sources and references
? Plain English
From Newcastle. For the world.
Assessment Table 1. GENERIC CRITERIA USED TO ASSESS AN ENGINEERING REPORT
BASIC REQUIREMENTS PRESENTATION CAPABILITY TECHNICAL CONTENT
Task Specification does the Report cover (completely) what was
asked for and does it do so at an appropriate (eg as specified or
suggested) length?
Organisation does the Report have clearly stated objectives
(appropriate to the Task Specification) and lead logically to a
statement of conclusions for each one?
Style and format for engineering Reports
does it conform to the normal English-speaking world
professional engineering conventions? (see separate Checklist at end)
Relevance and prioritisation is there a balanced choice of content
appropriate to the stated Report objectives and focussed on
reaching conclusions to these?
Sources identified for all data, information, opinions, etc with
appropriate citation from Report text as well as adequate
unambiguous referencing?
Deployment of evidence is this chosen and presented appropriately
and impartially to the issues under consideration?
Plain English is the presentation always clearly understandable to
technically-literate (but not necessarily specialist) readers? Eg, are
specialist terminology or acronyms defined?
Making a logically reasoned argument is the evidence systematically
evaluated to arrive at every outcome (opinion, assumption, deduction
or conclusion) by well-argued reasoning?
From Newcastle. For the world.
(Some) Literature
Biological strategies for improving osseointegration https://www.sciencedirect.com/science/article/pii/ S0169409X15000484
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC439 0115/
Biological surface coating/functionalisation to improve biological features (i.e. LbL) https://www.sciencedirect.com/science/article/pii/ S0142961213001154
https://www.sciencedirect.com/science/article/pii/ S0167779909002352
Additive manufacturing: 3D printing and bioprinting https://www.sciencedirect.com/science/article/pii/ S1005030218301798
In vitro models and cell therapy https://www.ncbi.nlm.nih.gov/pmc/articles/PMC591 0611/
Biological Complications and Their Management https://link.springer.com/article/10.1007/s11914- 018-0441-0
An overview on the orthopaedic standards (according ASTM International)
How to find good literature???
https://www.sciencedirect.com/science/article/pii/S0169409X15000484
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4390115/
https://www.sciencedirect.com/science/article/pii/S0142961213001154
https://www.sciencedirect.com/science/article/pii/S0167779909002352
https://www.sciencedirect.com/science/article/pii/S1005030218301798
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5910611/
https://link.springer.com/article/10.1007/s11914-018-0441-0
From Newcastle. For the world.
1.Scientific databases Scopus, Web of Science, Pubmed, Scholar Google, http://www.ncl.ac.uk/library/resources/ )
2. Use appropriate keywords (eg. dont be too broad or narrow in the research)
3. Give a look on the abstract. Is it pertinent to your project topic? YES: go on in the reading of the paper NO: move on the next one
4. Create your personal library that collects all the pertinent papers for your report (eg. in Excel?)
(Some) Literature
http://www.ncl.ac.uk/library/resources/
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Nursing
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3D printing versus Bioprinting on polymers
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MEC8049_Part2_L01_20.pdf
Home>Biology homework help> 3D printing versus Bioprinting on polymers
From Newcastle. For the world.
MEC8049: Orthopaedic engineering
Part 2: Dr Piergiorgio Gentile (STB, mezzanine floor, M2a)
Dr Ana Ferreira Duarte (STB, second floor 2.21)
From Newcastle. For the world.
Part 2 Date Room Lecturer Topic 9th March at 1 pm MERZ L302 AFD Introduction 10th March at 3 pm MERZ L302 AFD 1. Biological strategies for improving osseointegration
16th March at 1 pm MERZ L302 PG 2. Biological surface functionalisation to improve biological
features 17th March at 3 pm MERZ L302 PG 2. Biological surface coating technologies: Layer-by-Layer
23rd March at 1 pm MERZ L302 AFD 3. Additive manufacturing: bioprinting
24th March at 3 pm MERZ L302 AFD & PG 3. Additive manufacturing: 3D printing
27th April at 1 pm MERZ L302 AFD 4. Cell therapy 28th April at 3pm MERZ L302 PG 4. Bone models for orthopaedics
04th May at 1 pm MERZ L302 AFD 5. Biological Complications and Their Management 05th May at 3 pm MERZ L302 PG 6. An overview on the orthopaedic standards
11th -12th May Revision
week
AFD & PG Consultancy hours for the Report 2
From Newcastle. For the world.
1. Biological strategies for improving osseointegration (AFD)
Roach (2007) J Mater Sci Mater Med 18:1263 Gittens et al. (2011) Biomaterials 32:3395
Part 2
From Newcastle. For the world.
2. Biological surface functionalisation to improve biological features (PG)
Richardson et al. (2015) Science 348, aaa2491
Part 2
From Newcastle. For the world.
3. Additive manufacturing: bioprinting & 3D printing (AFD & PG)
Part 2
From Newcastle. For the world.
4. Cell therapy & bone models for orthopaedics (AFD & PG)
Part 2
Measurable data to predict the risks
Enables3Rs
Tissue and organ regeneration
Understanding/analysis and treatment of diseases (e.g. cancer, osteoarthritis, osteoporosis, etc.)
Drug discovery and evaluation
https://www.frontiersin.org/articles/10.3389/fbioe.2017.00040/full
From Newcastle. For the world.
5. Biological complications and their management (AFD)
Part 2
Figure 1. (ac) X-ray of a 36 year-old male patient few days following curettage of a low-grade chondrosarcoma of the left proximal tibia. (b and c) Follow-up radiographs 7 and 13 months following index surgery showing integration but no resorption of the artificial bone graft substitute. https://www.nature.com/articles/s41598-017-02048-w
https://www.nature.com/articles/s41598-017-02048-w/figures/1
From Newcastle. For the world.
6. An overview on the orthopaedic standards (PG)
Part 2
From Newcastle. For the world.
Assessment (%)
Written examination Report 1 (Part 1) Report 2 (Part 2)
90 min 4 long questions, 2 from each half of the course (Part 1 & 2)
Report 1 is due in week 30
Report 2 is due in week 37 (11 May*)
*These dates are to be confirmed
Assessment
From Newcastle. For the world.
Projects
Solve a device issues for a particular musculoskeletal
application (eg. THR, cancer drug screening, fixation
plates and screws, etc)
1. Antibacterial coatings on metals
2. Antibacterial coatings on polymers
3. Osseointegration of polymeric implants
4. Osseointegration of porous metallic implants
5. Bioprinting vs 3D printing on metals or polymers
6. Bioprinting of in vitro bone models
7. Issues and troubleshooting on bioprinting for
orthopaedics
8. More are coming!
From Newcastle. For the world.
Report Structure
Structure (limit 20 pages)
? Abstract (200 words)
? Introduction
? Motivation & background
? Literature Review
? Methods*
? Discussion and Analysis
? Conclusion
Marking criteria
? Capability (70%)
? Quality of background (30%)
? Description and justification of selected process and/or manufacturing route to solve specific implant issue (20%)
? Commercial viability, lifecycle, regulations and standards (20%)
? Organisation
? Relevance and prioritisation
? Deployment of evidence
? Making logically reasoned argument
Basic requirements Presentation (30%)
? Task specification
? Style and format
? Sources and references
? Plain English
From Newcastle. For the world.
Assessment Table 1. GENERIC CRITERIA USED TO ASSESS AN ENGINEERING REPORT
BASIC REQUIREMENTS PRESENTATION CAPABILITY TECHNICAL CONTENT
Task Specification does the Report cover (completely) what was
asked for and does it do so at an appropriate (eg as specified or
suggested) length?
Organisation does the Report have clearly stated objectives
(appropriate to the Task Specification) and lead logically to a
statement of conclusions for each one?
Style and format for engineering Reports
does it conform to the normal English-speaking world
professional engineering conventions? (see separate Checklist at end)
Relevance and prioritisation is there a balanced choice of content
appropriate to the stated Report objectives and focussed on
reaching conclusions to these?
Sources identified for all data, information, opinions, etc with
appropriate citation from Report text as well as adequate
unambiguous referencing?
Deployment of evidence is this chosen and presented appropriately
and impartially to the issues under consideration?
Plain English is the presentation always clearly understandable to
technically-literate (but not necessarily specialist) readers? Eg, are
specialist terminology or acronyms defined?
Making a logically reasoned argument is the evidence systematically
evaluated to arrive at every outcome (opinion, assumption, deduction
or conclusion) by well-argued reasoning?
From Newcastle. For the world.
(Some) Literature
Biological strategies for improving osseointegration https://www.sciencedirect.com/science/article/pii/ S0169409X15000484
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC439 0115/
Biological surface coating/functionalisation to improve biological features (i.e. LbL) https://www.sciencedirect.com/science/article/pii/ S0142961213001154
https://www.sciencedirect.com/science/article/pii/ S0167779909002352
Additive manufacturing: 3D printing and bioprinting https://www.sciencedirect.com/science/article/pii/ S1005030218301798
In vitro models and cell therapy https://www.ncbi.nlm.nih.gov/pmc/articles/PMC591 0611/
Biological Complications and Their Management https://link.springer.com/article/10.1007/s11914- 018-0441-0
An overview on the orthopaedic standards (according ASTM International)
How to find good literature???
https://www.sciencedirect.com/science/article/pii/S0169409X15000484
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4390115/
https://www.sciencedirect.com/science/article/pii/S0142961213001154
https://www.sciencedirect.com/science/article/pii/S0167779909002352
https://www.sciencedirect.com/science/article/pii/S1005030218301798
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5910611/
https://link.springer.com/article/10.1007/s11914-018-0441-0
From Newcastle. For the world.
1.Scientific databases Scopus, Web of Science, Pubmed, Scholar Google, http://www.ncl.ac.uk/library/resources/ )
2. Use appropriate keywords (eg. dont be too broad or narrow in the research)
3. Give a look on the abstract. Is it pertinent to your project topic? YES: go on in the reading of the paper NO: move on the next one
4. Create your personal library that collects all the pertinent papers for your report (eg. in Excel?)
(Some) Literature
http://www.ncl.ac.uk/library/resources/
Applied Sciences
Architecture and Design
Biology
Business & Finance
Chemistry
Computer Science
Geography
Geology
Education
Engineering
English
Environmental science
Spanish
Government
History
Human Resource Management
Information Systems
Law
Literature
Mathematics
Nursing
Physics
Political Science
Psychology
Reading
Science
Social Science
Home
Blog
Archive
Essay
Reviews
Contact
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